Host-directed vibroacoustic biosignature of viral respiratory infection

Andreas Schuh; Michael Morimoto; Piotr Kaszuba; Kevin Hammond; Jerry Swan; Krzysztof Krawiec; Nelson L Jumbe

Abstract

Respiratory infection testing, patient risk, and clinical costs are driven by disease prevalence, direct and downstream costs of false-positive/negative tests. In addition, false-positives decrease with disease prevalence, while -negatives increase. We developed a host response-based, easy to use, fast, low-cost, non-invasive respiratory infection detection system and used COVID-19 as a mechanism for assessing host vibroacoustic biosignatures based accuracy, sensitivity, and specificity to distinguish SARS-CoV-2 carriers from non-carriers in a diverse US, Indian, and African population. A vibroacoustic infrasound-to-ultrasound e-stethoscope that can detect a respiratory infection early in both asymptomatic and vaguely symptomatic, like cough, patients that could be a tool to meet current as well as future needs as viral pathogens come and go, seasonally and within pandemics.

Keywords: vibroacoustic; vibrome; biosignature; host response; acute lung injury

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